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DNA targeting specificity of RNA-guided Cas9 nucleases

Hsu, Patrick D, Scott, David A, Weinstein, Joshua A, Ran, F Ann, Konermann, Silvana, Agarwala, Vineeta, Li, Yinqing, Fine, Eli J, Wu, Xuebing, Shalem, Ophir, Cradick, Thomas J, Marraffini, Luciano A,

Journal:

Nature Biotechnology

Année:

2013

Langue:

english

Fichier:

PDF, 984 KB

english, 2013

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

Ran, F. Ann, Hsu, Patrick D., Lin, Chie-Yu, Gootenberg, Jonathan S., Konermann, Silvana, Trevino, Alexandro E., Scott, David A., Inoue, Azusa, Matoba, Shogo, Zhang, Yi, Zhang, Feng

Journal:

Cell

Année:

2013

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2013

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

Joung, Julia, Konermann, Silvana, Gootenberg, Jonathan S, Abudayyeh, Omar O, Platt, Randall J, Brigham, Mark D, Sanjana, Neville E, Zhang, Feng

Journal:

Nature Protocols

Année:

2017

Langue:

english

Fichier:

PDF, 2.07 MB

english, 2017

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Wu, Xuebing, Scott, David A, Kriz, Andrea J, Chiu, Anthony C, Hsu, Patrick D, Dadon, Daniel B, Cheng, Albert W, Trevino, Alexandro E, Konermann, Silvana, Chen, Sidi, Jaenisch, Rudolf, Zhang, Feng, Sha

Journal:

Nature Biotechnology

Année:

2014

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2014

ESWT and Ultrasound Imaging of the Musculoskeletal System || Elbow

Bachmann, C. E., Gruber, G., Konermann, W., Arnold, A., Gruber, G. M., Ueberle, F., Gerdesmeyer, L.

Année:

2001

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2001

Mass Spectrometry Methods for Studying Structure and Dynamics of Biological Macromolecules

Konermann, Lars, Vahidi, Siavash, Sowole, Modupeola A.

Journal:

Analytical Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 6.89 MB

english, 2014

Corrigendum: Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease

Dahlman, James E, Abudayyeh, Omar O, Joung, Julia, Gootenberg, Jonathan S, Zhang, Feng, Konermann, Silvana

Journal:

Nature Biotechnology

Année:

2016

Langue:

english

Fichier:

PDF, 119 KB

english, 2016

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Abudayyeh, O. O., Gootenberg, J. S., Konermann, S., Joung, J., Slaymaker, I. M., Cox, D. B. T., Shmakov, S., Makarova, K. S., Semenova, E., Minakhin, L., Severinov, K., Regev, A., Lander, E. S., Kooni

Journal:

Science

Année:

2016

Langue:

english

Fichier:

PDF, 2.60 MB

english, 2016

Site-Directed Mutagenesis Combined with Oxidative Methionine Labeling for Probing Structural Transitions of a Membrane Protein by Mass Spectrometry

Yan Pan, Leonid Brown, Lars Konermann

Journal:

Journal of the American Society for Mass Spectrometry

Année:

2010

Langue:

english

Fichier:

PDF, 875 KB

english, 2010

Sonographie des Ellenbogengelenks bei der Radiusköpfchenfraktur

T. Kessler, H. Winkler, C. Weiss, W. Konermann, G. Gruber

Journal:

Der Orthopäde

Année:

2002

Langue:

german

Fichier:

PDF, 101 KB

german, 2002

Modafinil zur Behandlung exzessiver Tagesschläfrigkeit trotz nCPAP-Therapie beim obstruktiven Schlafapnoe-Syndrom (OSAS) – Ergebnisse einer multizentrischen Beobachtungsstudie

Martin Konermann, Hartmut Grüger, Ralf Warmuth

Journal:

Somnologie - Schlafforschung und Schlafmedizin

Année:

2007

Fichier:

PDF, 162 KB

2007

Modafinil zur Behandlung exzessiver Schläfrigkeit bei Patienten mit Schichtarbeitersyndrom

H. Mittendorf, J. Groth, M. Konermann, K. Freund, I. Fietze

Journal:

Somnologie - Schlafforschung und Schlafmedizin

Année:

2010

Langue:

german

Fichier:

PDF, 333 KB

german, 2010

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

Konermann, Lars, Pan, Jingxi, Liu, Yu-Hong

Journal:

Chemical Society Reviews

Année:

2011

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2011

Neue DGNB-Kriterien für ökologische Qualität

Bayer, Frank, Konermann, Reinhard

Journal:

Bautechnik

Année:

2012

Langue:

german

Fichier:

PDF, 339 KB

german, 2012

Teachers' organizational citizenship behaviour: Considering the roles of their work engagement, autonomy and leader–member exchange

Piety Runhaar, Judith Konermann, Karin Sanders

Journal:

Teaching and Teacher Education

Année:

2013

Langue:

english

Fichier:

PDF, 291 KB

english, 2013

Optical control of mammalian endogenous transcription and epigenetic states

Konermann, Silvana, Brigham, Mark D., Trevino, Alexandro, Hsu, Patrick D., Heidenreich, Matthias, Le Cong,, Platt, Randall J., Scott, David A., Church, George M., Zhang, Feng

Journal:

Nature

Année:

2013

Langue:

english

Fichier:

PDF, 2.28 MB

english, 2013

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

Nishimasu, Hiroshi, Ran, F. Ann, Hsu, Patrick D., Konermann, Silvana, Shehata, Soraya I., Dohmae, Naoshi, Ishitani, Ryuichiro, Zhang, Feng, Nureki, Osamu

Journal:

Cell

Année:

2014

Langue:

english

Fichier:

PDF, 5.97 MB

english, 2014

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

Ran, F. Ann, Hsu, Patrick D., Lin, Chie-Yu, Gootenberg, Jonathan S., Konermann, Silvana, Trevino, Alexandro E., Scott, David A., Inoue, Azusa, Matoba, Shogo, Zhang, Yi, Zhang, Feng

Journal:

Cell

Année:

2013

Langue:

english

Fichier:

PDF, 423 KB

english, 2013

Conformational Dynamics of Free and Catalytically Active Thermolysin Are Indistinguishable by Hydrogen/Deuterium Exchange Mass Spectrometry †

Liu, Yu-Hong, Konermann, Lars

Journal:

Biochemistry

Année:

2008

Langue:

english

Fichier:

PDF, 5.61 MB

english, 2008

Acid-Induced Denaturation of Myoglobin Studied by Time-Resolved Electrospray Ionization Mass Spectrometry †

Konermann, L., Rosell, F. I., Mauk, A. G., Douglas, D. J.

Journal:

Biochemistry

Année:

1997

Langue:

english

Fichier:

PDF, 154 KB

english, 1997

Monitoring Reaction Kinetics in Solution by Continuous-Flow Methods: The Effects of Convection and Molecular Diffusion under Laminar Flow Conditions

Konermann, Lars

Journal:

Journal of Physical Chemistry A

Année:

1999

Langue:

english

Fichier:

PDF, 91 KB

english, 1999

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

Konermann, Silvana, Brigham, Mark D., Trevino, Alexandro E., Joung, Julia, Abudayyeh, Omar O., Barcena, Clea, Hsu, Patrick D., Habib, Naomi, Gootenberg, Jonathan S., Nishimasu, Hiroshi, Nureki, Osamu,

Journal:

Nature

Année:

2014

Langue:

english

Fichier:

PDF, 6.46 MB

english, 2014

Teachers' work engagement: Considering interaction with pupils and human resources practices as job resources

Runhaar, Piety, Sanders, Karin, Konermann, Judith

Journal:

Journal of Applied Social Psychology

Année:

2013

Langue:

english

Fichier:

PDF, 195 KB

english, 2013

Die Beteiligung Dritter an Transferrechten im Profifußball

Bahners, Frank, Konermann, Thorge

Journal:

Kölner Schrift zum Wirtschaftsrecht

Année:

2013

Langue:

german

Fichier:

PDF, 114 KB

german, 2013

Die zementfreie Hohlschaft-Hüftendoprothese zur Reduzierung des intramedullären Druckes

Barden, B, Seel, W, Löer, F, Konermann, H

Journal:

Zeitschrift für Orthopädie

Année:

2004

Langue:

german

Fichier:

PDF, 528 KB

german, 2004

Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease

Dahlman, James E, Abudayyeh, Omar O, Joung, Julia, Gootenberg, Jonathan S, Zhang, Feng, Konermann, Silvana

Journal:

Nature Biotechnology

Année:

2015

Langue:

english

Fichier:

PDF, 725 KB

english, 2015

Intense Pulsed Light Sintering of CH 3 NH 3 PbI 3 Solar Cells

Lavery, Brandon W, Kumari, Sudesh, Konermann, Hannah, Draper, Gabriel, Spurgeon, Joshua Michael, Druffel, Thad L

Journal:

ACS Applied Materials & Interfaces

Année:

2016

Langue:

english

Fichier:

PDF, 5.21 MB

english, 2016

Mechanism of Protein Supercharging by Sulfolane and m -Nitrobenzyl Alcohol: Molecular Dynamics Simulations of the Electrospray Process

Metwally, Haidy, McAllister, Robert G., Popa, Vlad, Konermann, Lars

Journal:

Analytical Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 3.54 MB

english, 2016

How to Run Molecular Dynamics Simulations on Electrospray Droplets and Gas Phase Proteins: Basic Guidelines and Selected Applications

Konermann, Lars, Metwally, Haidy, McAllister, Robert G., Popa, Vlad

Journal:

Methods

Année:

2018

Langue:

english

Fichier:

PDF, 1.81 MB

english, 2018

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d

Zhang, Cheng, Konermann, Silvana, Brideau, Nicholas J., Lotfy, Peter, Wu, Xuebing, Novick, Scott J., Strutzenberg, Timothy, Griffin, Patrick R., Hsu, Patrick D., Lyumkis, Dmitry

Journal:

Cell

Année:

2018

Langue:

english

Fichier:

PDF, 8.11 MB

english, 2018

Dimerization Interface of Osteoprotegerin Revealed by Hydrogen-deuterium Exchange Mass Spectrometry

Xiao, Yiming, Li, Miaomiao, Larocque, Rinzhi, Zhang, Fuming, Malhotra, Anju, Chen, Jianle, Linhardt, Robert J., Konermann, Lars, Xu, Ding

Journal:

Journal of Biological Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 11.16 MB

english, 2018

Author Correction: Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

Joung, Julia, Konermann, Silvana, Gootenberg, Jonathan S, Abudayyeh, Omar O, Platt, Randall J, Brigham, Mark D, Sanjana, Neville E, Zhang, Feng

Journal:

Nature Protocols

Année:

2018

Fichier:

PDF, 203 KB

2018

Charging and supercharging of proteins for mass spectrometry: recent insights into the mechanisms of electrospray ionization

Konermann, Lars, Metwally, Haidy, Duez, Quentin, Peters, Insa

Journal:

The Analyst (Royal Society of Chemistry)

Année:

2019

Fichier:

PDF, 6.75 MB

2019

A novel serum-free medium for the isolation, expansion and maintenance of stemness and tissue-specific markers of primary human periodontal ligament cells

JÃ¤ger, A., Heim, N., Kramer, F.J., Setiawan, M., Peitz, M., Konermann, A.

Journal:

Annals of Anatomy - Anatomischer Anzeiger

Année:

2020

Fichier:

PDF, 1.42 MB

2020

Formation of Gaseous Proteins via the Ion Evaporation Model (IEM) in Electrospray Mass Spectrometry

Aliyari, Elnaz, Konermann, Lars

Journal:

Analytical Chemistry

Année:

2020

Fichier:

PDF, 1.13 MB

2020

Short stature in a mother and daughter with terminal deletion of Xp22.3

Schwinger, Eberhard, Kirschstein, Martin, Greiwe, Monika, Konermann, Thora, Orth, Ulrike, Gal, Andreas

Journal:

American Journal of Medical Genetics

Année:

1996

Fichier:

PDF, 316 KB

1996

Equilibrium unfolding of proteins monitored by electrospray ionization mass spectrometry: distinguishing two-state from multi-state transitions

Lars Konermann, D. J. Douglas

Journal:

Rapid Communications in Mass Spectrometry

Année:

1998

Langue:

english

Fichier:

PDF, 175 KB

english, 1998

Stability of a highly charged noncovalent complex in the gas phase: holomyoglobin

Yu-Luan Chen, J. M. Campbell, B. A. Collings, Lars Konermann, D. J. Douglas

Journal:

Rapid Communications in Mass Spectrometry

Année:

1998

Langue:

english

Fichier:

PDF, 177 KB

english, 1998

Stopped-flow electrospray ionization mass spectrometry: a new method for studying chemical reaction kinetics in solution

Beata M. Kolakowski, Douglas A. Simmons, Lars Konermann

Journal:

Rapid Communications in Mass Spectrometry

Année:

2000

Langue:

english

Fichier:

PDF, 84 KB

english, 2000

Über Methoxychromonole und das Schall-Drallesche Abbauprodukt des Brasilins. (IV. Mitteilung zur Brasilin- und Hämatoxylin-Frage)

P. Pfeiffer, H. Oberlin, E. Konermann

Journal:

European Journal of Inorganic Chemistry

Année:

1925

Langue:

german

Fichier:

PDF, 841 KB

german, 1925

ChemInform Abstract: Primary Processes and Structure of the Photosystem II Reaction Center. Part 5. Modeling of the Fluorescence Kinetics of the D1-D2-cyt-b559 Complex at 77 K

L. KONERMANN, G. GATZEN, A. R. HOLZWARTH

Journal:

ChemInform

Année:

1997

Fichier:

PDF, 26 KB

1997

2003 Fred Beamish Award Lecture — Exploring the Dynamics of Biological Systems by Mass Spectrometry

Lars Konermann

Journal:

ChemInform

Année:

2005

Fichier:

PDF, 8 KB

2005

ChemInform Abstract: Hydrogen Exchange Mass Spectrometry for Studying Protein Structure and Dynamics

Lars Konermann, Jingxi Pan, Yu-Hong Liu

Journal:

ChemInform

Année:

2011

Fichier:

PDF, 18 KB

2011

Sustained NF-kappaB activity in chronic lymphocytic leukemia is independent of genetic and epigenetic alterations in the TNFAIP3 (A20) locus

Lukas P. Frenzel, Rainer Claus, Nadine Plume, Janine Schwamb, Carolin Konermann, Christian P. Pallasch, Julia Claasen, Reinhild Brinker, Bernd Wollnik, Christoph Plass, Clemens-Martin Wendtner

Journal:

International Journal of Cancer

Année:

2011

Langue:

english

Fichier:

PDF, 330 KB

english, 2011

Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches

Lars Konermann, Xin Tong, Yan Pan

Journal:

Journal of Mass Spectrometry

Année:

2008

Langue:

english

Fichier:

PDF, 296 KB

english, 2008

Protein-folding kinetics and mechanisms studied by pulse-labeling and mass spectrometry

Lars Konermann, Douglas A. Simmons

Journal:

Mass Spectrometry Reviews

Année:

2003

Langue:

english

Fichier:

PDF, 398 KB

english, 2003

Mass spectrometry combined with oxidative labeling for exploring protein structure and folding

Lars Konermann, Bradley B. Stocks, Yan Pan, Xin Tong

Journal:

Mass Spectrometry Reviews

Année:

2010

Langue:

english

Fichier:

PDF, 338 KB

english, 2010

From Small-Molecule Reactions to Protein Folding: Studying Biochemical Kinetics by Stopped-Flow Electrospray Mass Spectrometry

Beata M Kolakowski, Lars Konermann

Journal:

Analytical Biochemistry

Année:

2001

Langue:

english

Fichier:

PDF, 91 KB

english, 2001

Effects of ground loop currents on signal intensities in electrospray mass spectrometry

Richard A. Ochran, Lars Konermann

Journal:

Journal of the American Society for Mass Spectrometry

Année:

2004

Langue:

english

Fichier:

PDF, 167 KB

english, 2004

Folding and Assembly of Hemoglobin Monitored by Electrospray Mass Spectrometry Using an On-line Dialysis System

Brian L. Boys, Lars Konermann

Journal:

Journal of the American Society for Mass Spectrometry

Année:

2007

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2007